Both my children, girls ages 6 and 9 are currently taking 800 mg....

Astonishing! My 8-year-old daughter, whose age your 6-and 9-year-olds perfectly bracket, began mentioning "depression" yesterday; Monday, 2/16/09; a word we didn't know she KNEW. As she watches me write this, she says she was depressed since last Thursday, day after an amoxicillin injection.

It became a real concern at dinner tonight, when we had 2 favorites, French bread and broccoli, (and spaghetti, which she also likes.) She wanted none of it and said she was depressed and it was causing her not to be able to eat, though she said she had tried to eat yesterday even though not wanting to. We have never discussed depression or its effects with her! (She DID learn to speak long before her peers, so after stressing enourmously during the meal, during which we asked her if there were "mean girls" --only one, especially mean, anyway; only a few mean, etc.) and asking whether her throat or any other part hurt or if she felt sick (negative...) we were pretty upset, and she had red face & tears, all very unusual.

We DID wonder if this weekend's 1 a.m. trip to emergency room for strep throat and amoxicillin injection (she ASKS for injections, these last 3 years, being quite a food conoissseur, she can taste oral meds mixed with ANY tricky bait and hates it). She had always received Rocephin injections, even, recently, one in EACH leg, last time, as her weight called for double injections, as it is apparently an unusually irritating injectable....

So we were gratified for ONE simple injection this time, and "--cillin" part of drug name and milky oil suspension appearance of drug reminded us of OUR days of painful but unusually, at that time, EFFECTIVE penicillin shots we'd both gotten.

Anyway, our daughter seemed so upset, and yet so unusually grown up in saying she was "depressed" and had prayed that it end, to no aviail, I got up from dinner and Googled "amoxicillin, depression" and VOILA, your response and next one so amazingly similar, I printed them and took them to dinner table, to have her read aloud to us, complimenting her on how grown up she was to describe herself as depressed. (Also, she got 5 minutes of reading towards going to Fiesta Texas on a reading program--how many kids will have "Amoxicillin and depression--5 minutes" on their forms, I wonder...

Thanks for taking time to post this! I am only now learning that there is no need to argue or feel alone about much of anything anymore, or rely on just one friend or medical practitioner--Until they censor the 'net, just GOOGLE IT. Bless you. And, any men, google "bladeless vasectomy" or "Matt Herring.com" and read my 8-year long compendium of side effects doctors do not talk about. Ednorandrewrowe; & grateful and much cheered wife & daughter.