I started Zoloft 50 mg about two months ago. I must say i have absolutely no complaints! I was prescribed the medication due to mood swings and depression before and while i was on my period..I take my zoloft and night and within a few days i noticed my mood swings started to go away! I felt more patient and less anxious and pissy all the time. Not to mention before zoloft i was tossing and turning all night long thinking about stuff that was stressing me out..Now, i sleep like a baby! the occasional nightmare every now and then but nothing i cannot handle. The only thing i have to say is when i take it at night i have to have water with it. At least 5 sips if not the heartburn is unbelievable!! So if you are thinking about it make sure you take it with something to drink..I have had no weight gain,no headaches,no suicidal thoughts and no nausea! Also, the sex drive has gone down a little bit, but not much. I would recommend this medicine to anyone! It dosent make you like a zombie or out of your mind. It is amazing!!