I have been taking Omeprazole for about 6 months. I've had a terrible itchy rash on my chest, abdomen, back and upper arms and legs this whole time. I've tried all sorts of prescribed creams and steroids, but nothing made it go away. It just occurred to me tonight after reading all of these side effects that Omeprazole is most likely the culprit. I won't be taking another dose of it! I'll just have to suffer with the acid reflux until I find a new drug to take.