I am a male in my 30s and I am predisposed to situational anxiety hypersensitivity and phase of life triggered depression. 90% of the year I am fine with no problems with depression or anxiety. I have had 6 treatments of amoxicillin over the last 2 years for sinus infections and wisdom tooth extractions. In each case, within 72 hours of the start of treatment, I experience constant depressed mood and hopeless and experience evening crying spells as a release from severe depression all day. In all 6 cases, within 48 hours of the last dose of amoxicillin, the depression subsides and my mood reaches a normal state. My doctor at the time did not attribute the depression to the antibiotic since I suspect it isn't listed in his PDR and did not show up with statistical significance in clinical trials. I don't go to that doctor any longer due to this and have a new doctor that has 20 years of experience and noted a lot of anecdotal evidence of amoxicillin triggering depression in those that might be predisposed to situational anxiety, panic attacks and/or stress/phase of life induced depression.