I was diagnosed with Ulcerative Colitis in Aug of 2005 and in remission for 9 months. I came out of remission in May of 2006 and have been on prednisone since then until right now. I would go on high dose of steriods, try a new medication, and try to ween off and get sick right as I went off the steriods, so I'd have to do this rollercoaster all over again. For a year now, I have been on steady, high doses between 60-100mg daily with no break. I tried to go below 20 and got really sick again and have run out of medication to try, so I had my colon removed. Right now, we are trying to ween me off the prednisone (since i dont need it for my disease anymore) but have to go over 3-4 months and very slowly since I've been on it so long to prevent the body from doing all the fun things it does when you stop prednisone cold turkey, like a coma and stuff. I'm SICK of the side effects this drug has had on me! I have had countless sleepless nights, heartburn, night sweats, weight gain (i went from 140 lbs to 215 lbs right now), the moon face to where i can't even recognize myself, red face, weird skin, sensitive teeth, thinning hair, hungry ALL the time, stretch marks, all the weight is in my stomach, the buffalo hump, high blood pressure and high eye pressures etc. These are all the side-effects that have been horrible on this miserable drug. I'm sure there are a lot more I am forgetting, but these are the ones that come to mind. Hopefully they will go away once I am able to finally get off this drug!