All this just blows me away-I have been on Toprol XL 100 (currently 51 High blood pressure-hypertension) for maybe 4 or 5 years and have no sex drive, shoulders have begun to ache like they are broken or dislocated(daily), can't sleep at times, ringing in ears has gotten worse over the years, beginning to be tired earlier in the evening. 100 seems to be more than anyone on this blog so I must have it bad. My pharmacist alerted me to this drug not being made anymore so there is a subsitute, not sure what but I will get the call on that shortly. I have a doctor's appointment on 3/31, I think I am going to get something changed. Bad thing is this was the 3rd heart med I took that worked for me.