Wow, there's alot of comments about this drug on both sides of the plate. I've been off and on Effexor four about 5 years now. I never had any bad side effects coming off Effexor. I take a whopping 300mg a day, and it keeps me out of trouble. I am also bipolar and take lithium which is a mood stabiliser. Effexor is NOT a mood stabiliser, anyone who tells you so, is wrong. It is an anti-depressant and only an anti-depressant. With any antidepressant there is the chance of weight gain, but I personally have lost weight on the drug, and perhaps like all drugs of this category, one should have their thyroid checked, to make sure that their weight gain is not due to hypothyroidism. Sexual side effects, like any anti-depressant, are always mentioned as a possible side effect, though I haven't experienced any change...maybe these affects are caused by depression and not always necessarily by the drug. All drugs work differently because we alll have our own specialized brain chemistry. Finding the right drug for you is important. YOu cannot make this decision until you've taken the full course of the drug which is 6-8 weeks for full effect. The first few weeks are usually when you're are going to feel any strange effects as your body gets used to this new element in your system. Good Luck to all.