I have been on Biaxin XL 500 mg - 2 pills taken at the same time once a day. Today would be the 4th dose. I was sure to take the pills on a full stomach. My sinus infection seems a little better but I'm feeling totally lousy. I've had a headache and I haven't been able to sleep at all for the last 3 nights. I lie there with a pressure in my chest. Even after missing only 1 night of sleep I felt horrible and I'm sure it wasn't only from missing the sleep. Biaxin is definitely affecting my whole body. I've been on antibiotics before and never had any kind of reaction like this. I had called the pharmacist and they said that this is a very potent antibiotic, hard on the body but best on the market. True it may clear up an infection but at what cost. After reading all these side effects I'm definitely calling my doctor today and asking for a different medication. Thanks for this website.