My son was given Omnicef to treat an ear infection one day before his first birthday in 2003. The next morning after his first dose he woke up covered from head to toe in a horrible rash. His eyes were swollen almost completely shut, and he was "zoned" out. He obviously was in lots of pain and very cranky and couldn't sleep. We took him to the ER twice, first time the doctor said he must be allergic to the Omnicef but isn't experiencing any discomfort. Several hours later, well after midnight, he still was very cranky and couldn't sleep and we took him back to the ER where the doctor gave him an injection of Benadryl. My son from that point was very "difficult", horrible melt-downs, no eye-contact, no communication, except for his violent melt-downs. This lasted for years.