After being treated for COPD, first with prednisone (some years ago) and with Advair subsequently, I have suffered waves of extreme fatigue and panic attacks. I don't know if it was the original prednisone treatment or the use of Advair. The dosage was reduced last year from 500/50 to 250/50, but the waves of attacks continue. I cannot attribute the condition to anything else. I am not on any other medications except Duoneb. I do not have high-blood pressure. I have developed a pad of fat on my abdomen, but am otherwise slender. Considering that I eat very little, I am probably overweight inspite of my weighing only 120 pounds. Has anyone else suffered with my problems following the use of Advair (or prednisone)?.