I received yet another email from someone who has had a recent MRI due to memory difficulties and the MRI indicated brain shrinkage. This drug is breaking the blood brain barrier, causes depression, and is shrinking the brain. I know of 3 people who began Lisinopril and over a period of less than 2 years, have had MRI and their brains indicate shrinkage. We are wondering why Alzheimers is becoming an epidemic. More people are being prescribed Blood Pressure medicines at earlier ages, particularly Ace Inhibitors because they are cheap and these drugs are pentrating the blood brain barrier and causing a drug induced brain damage that mimicks Alzheimer symptoms. It begins to appear as depression, so, they treat the depression with anti-depressants. They improve for a period of time and then the symptoms of memory loss, difficulty retaining, concentration issues, mental sluggishness begin to present again. The Doctors are in denial, not us who are posting these symptoms. The obvious is oblivious. You cannot take a healthy individual who never took anything more than an aspirin and within 17 month of taking this medication have depression, memory issues and brain shrinkage. I hope if there are any Doctors that read this site, they pay attention to their patients and watch those people on Ace Inhibitors who then follow a pattern of memory problems and depression. It's much more than depression. I bet if all those people who experience memory difficulties got and MRI, there brains would show shrinkage.