Sometimes the symptoms of depression, anxiety, headaches, short temper and hot flashes are due to out-of-balance TSH and your medication may need to be adjusted. That's been the case with me in the past and it has worked. Usually the doctor increases the dosage and things go back to normal. However, my last increase has produced opposite results. I am on 0.137 now and I feel very, very anxious, fearful, and get easily upset. I feel hot flashes as I get angry and generally feel quite depressed. I've also gained about 6 pounds in the last two months, which should is bizarre, as higher dosage usually means higher metabolism rate and weight loss. I am confused. Should I go back to my old dosage where I felt better, except for the onset of weight gain.