I changed to Femcon Fe from orthotricyclen after some break-through bleeding. Within the first few days I had nausea, vomiting, and cramping. But the worst side effect was the mood swings. I became very angry and restless. I felt like a totally different person, and the people around said so too. Bottom line is I switched back to orthotricyclen before my first pack of femcon fe was even finished...I would rather have breakthrough bleeding than feel like my blood is boiling with rage.