I'm 41 and approximately 115 lbs. I've been taking Doxycycline Hyclate (100mg) for only 3 days now and so far I'm still feeling my normal self. I have 4 more days to take the medicine before completing my dosage and I hope to continue to feel the same way. I must say that when I take it, in the morning and early evening, I drink lots of water with it and I eat a complete meal, which is what I do with any prescribed medication that I may have to take unless otherwise specified. I don't know if this is why I'm not feeling any side effects, but so far it seems to be working for me.