I have been taking lisinopril for about 2 1/2 years now. About 4...

its sounds like many side affects others here are having, i undestand that feeling of a sore lump in the throat, i was told here it hives in the throat from the medication, for me it comes and goes and actually feels like pressure in the soft spot of the throat where the colar bone meets the neck.

as far as MS, usually MS occurs in your 20s and 30s, and you would feel clumsy walking , and trip into things. If you are in your 40s or older i would doubt its that.

Tell the nuro doctor you are taking lisinopril, and get a second opinion if this doctor does not want to change your med. I am still on lisinoprol because the side affects are mild for now.

The lump in the throat seems to have 3 causes. One is the windpipe getting sore from coughing, another is the esophagus getting sore from swallowing the irritating stuff coming up from the lungs, and the other is the thyroid, which is an organ at the base of the neck, right about where joepro50 above describe the soft spot.

The thyroid sits on top of the lungs and, much like a carburator, monitors the incoming airflow (from the heaving of breathing) and administers a small amount of hormone to help the body release fuel to burn with that air. When we exercise the heaving increases, which is sensed by the thyroid and it releases more hormone. Yawning is an attempt by the body to not only increase oxygen in the blood, but also stretch the thyroid to get it to release some of this hormone. So, the excessive yawning side-effect of lisinopril is one indication of thyroid concerns, as is the lump in the throat at the base of the neck.

Though I'm no expert, I think what happens goes something like this: The thyroid requires certain nutrition such as trace minerals and some proteins to function well, and, when it doesn't get what it needs, it tends to swell a bit to try harder to function.

Many of the same trace minerals and proteins are also used in the immune system. Lisinopril puts a load on the immune system as detoxifies from the medication and its manufacturing byproducts (which I think are higher with the generic drugs) and also what all these things break down into in the body. This extra load can eventually deplete the body of nutrition, reducing effectiveness of the immune system and causing problems of increasing side effects. But there is another effect beyond the immune system on other systems like the thyroid that just happen to share some of these same nutrients.

Trace minerals like selenium (used in very small quantities by the thyroid) and zinc are critical in chemical detoxification. Cysteine is a protein important for lung tissue, immune system detoxification and thyroid receptor cites. (Broccoli is a good source of selenocysteine, and good for the immune system, the lungs, and the thyroid system. Kelp is also rich in trace minerals; brewer's yeast too.)

Another permanent side effect that I've experience from my brief encounter with lisinopril, is that now my stomach seems to digest more weakly. And of course, mineral absorption depends on strong digestion. So here's another likely source mineral depletion caused by this medication.

Post lisinopril, I can't seem to get enough minerals without supplementation, so I take some general purpose, high-quality, well-balanced mineral supplements. Over the years I've been able to reduce my supplementation quite a bit, but 5 years later, if I don't supplement, then after about 3 or 4 days my shortness of breath, tightness in the chest, yawning, and many of the other lisinopril symptoms significantly increase.