every time I have a cortisone shot, I get horrible body aches all over in joints and muscles and headache.It happens every time. My grandmother had the same thing. I thought everyone had this. I had the injection in my knee today and then went shopping. 5 hours later, I was aching so bad, I had to go to bed. Tylenol doesn't touch it. I hate cortisone shots. I was really disparate when I agreed to this one. The shot didn't hurt much as they used the freezing thing. The doc is an orthopedic doc and he is good. He replaced my hip and it is wonderful and quicker recovery than my first one on the other side. Next we do the synvisc shots, He already tried the meniscus surgery. We are just trying to postpone replacement as I am only 58.