I was recently prescribed Doxy for Lyme disease. From the time I took my first dose until now, 3 days later, I have had horrible cramping. Similar to menstrual cramps, but worse. I also have a constant headache, though I'm not sure if the headache is caused my the meds or the Lyme disease itself. I have found I absolutely can NOT take this medication on an empty stomach. I drink the recommended amount of water and eat a few crackers when I take it. Seems to take the edge off a bit. I currently take a prescription medication for GERD, but I have been having the worst heartburn ever. Not so sure if I will be able to deal with 18 more days on this medication. I will probably call my doctor first thing Monday morning to see what my options are.