I just had my 2nd lupron shot, and I have to say I am fine, no negative side effects. My first shot, it had stop my hot flashes and I was sleeping better, after getting close to the 28 day mark , I started to feel the pain and discomfort that I had before the shots and agree to the 2nd shot. I was having hot flashes before the 2nd shot and still have them, but the most important thing is I am not having the pain which was horrible pain that I needed tylond codeine to help me. I have not seen any weight gain, I stay active and work out even harder , no increase in appetite, so I will take it and see each month if any side effects come upon me, but so far I am good. I have to say that I was already into menopause before these shots.