I was on the Depo Lupron for 4 months. I had all the typical side effects; hot flashes, acne, night sweats, and weight gain. All which I was told by my Doctor that are all normal.... I asked if there were any other major side effects and he said some, but with a very low occurrence and left it at that. Well, I started gaining more weight... I put on 15 pounds in less then a month. I had a lump on the side of my throat and couldn't figure out why I was so tired all the time, why my hair was falling out, and why my skin was so dry. I went online and read a little more about the drug and it's side effects. Yep, right there it said it was known to cause thyroid problems. So now I have to live with hypothyroidism, something that is manageable, but will never go away. All because this drug. I say if you don't need to take it, DON"T!