I took Benadryl for over a year with my topamax (for migraines). The doctor said it was ok so I continued and got a good nights sleep. A few weeks ago I got up and went to the bathroom. My urine was cloudy and smelled terrible. I started drinking water and even drank a full glass before I went to bed. I woke up with the same problem. I quit taking the topamax and benadryl.My urine cleared up the next day. About a week later I took a benadryl before bed (no topamax) and woke up with the same terrible smell in my urine. I know think that long term use is going to cause kidney problems.