I recently had a bad reaction to Benadryl also. I have been taking Remicade for over a year now which has been a miracle for my Crohns. Last week after the benadryl went into the IV I started having a really bad reaction. First, I felt restless and twitchy, then I felt like all my muscles were numb and I had to stretch everywhere. I had to stand because my hips and back hurt so much. It was scary to me and I know I freaked out the other Remicade patient. My husband rushed a hydrocodone to me for the pain and it also helped me feel less restless. Next time we will half the Benadryl and take a hydrocodone to begin with.