I was on Desogen for over a year and a half, during which time I had symptoms similar to IBS. Frequent diarrhea, severe intestinal cramps after almost every meal, bloating, weight gain, gas, and subsequent depression and lethargy. I even went to see a GI specialist, who asked if I had recently started taking a new birth control or had any other hormonal changes. At the time I had been taking Desogen for a year, so I didn't connect the two. Now 9 months later I finally got off of Desogen and have had no more IBS symptoms. The doctors I have spoken to since then have no explanation for it, aside from 'hormones can do strange things sometimes'. I don't know if I have been depressed since I have been on Desogen, aside from the anxiety and depression caused by IBS, but I am so glad not to be on it anymore. I hope the symptoms stay gone and I am able to lose the weight I gained while on it.