I started reading articles about links between depression and ddp...

I started reading articles about links between depression and ddp-4, Which Januvia is a ddp-4 inhibitor. after reading this forum and noticing that people experience depression on this drug. I had depression as one of the side effects on this drug but what I noticed it was not easy to get off the drug. It took me a week of sleepless nights and anxiety and panic attacks which I never had until i took the drug. I am doing better but from what I read it takes a month for Januvia to leave your system. So my question would be why would a doctor who knows of family background of depression in family history would prescribe this junk. I would think that if you have a predisposition to a disease that it would be taking into account. What this tells me is that our doctors are not doing their homework on the stuff they are giving us and we are having to do tha t for them. What am I paying for then? What I got from my research was that lower levels of ddp-4 is seen in patients with depression. I found studies by searching on Dipeptidyl peptidase IV and depression. Copyright © 1999 Elsevier Science Ltd. All rights reserved. Dipeptidyl peptidase IV and adenosine deaminase activity: Decrease in depression References and further reading may be available for this article. To view references and further reading you must purchase this article. Serenay Elgün, , a, Aytaç Keskinegea and Hakan Kumbasarb a Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, University of Ankara, 06100 Sihhiye, Ankara, Turkey b Department of Psychiatry, Consultation–Liaison Unit, Faculty of Medicine, University of Ankara, Dikimevi, Ankara, Turkey Received 22 December 1998; accepted 15 May 1999. Available online 17 September 1999. Abstract Dipeptidyl peptidase IV (DPPIV) and adenosine deaminase (ADA), two T cell associated enzymes, are known to have a possible interaction and play essential roles in immune system functioning. On the other hand, depression has been shown to be accompanied with some immune-inflammatory alterations. In this regard, in order to make a contribution to the understanding of the ongoing immune disturbances in depression, serum DPPIV and ADA activities were determined in minor and major depressives and compared with healthy controls. Both enzyme activities were found to be decreased in major depressives compared to controls while only DPPIV activity was significantly lower in major depressives than the minor depressives. There were significant inverse relationships between enzyme activities and the severity of depression. Moreover, a positive intracorrelation was found between decreased DPPIV and ADA levels. The correlated decrease in DPPIV and ADA, might be a further support for their possible association. Results also suggest that decreased enzyme activities might reflect the impaired immune state in depression while major depressed patients might have a greater tendency to immune dysfunction than the minor depressed ones.