Was prescribed Sulfameth/Trimethoprim for acne when erythromycin and doxycycline were not enough. Dermatologist simply asked "Is there anything that are you allergic to?" I said, "Not that I know of." Took it well for first six days. Looking back, I felt probably the most lethargic during this time, at a job that I loved the most. On the 7th day, after having a great time with the new love in my life, I noticed a heaviness, tingling, and warmness affecting my legs. Went into work feeling too warm. Left about 20 mins in. Had incredibly bad fever this night. Went home, took another Sulfa/Trimeth pill (hadn't linked the problem). Woke up about two hours later, worse than ever. Flu like symptoms, blurred vision, couldn't sleep, and red rash developing over body. Took next night off of work. Went into emergency room with a panic attack and left side of body numb. Docs didn't know what it was. Blood pressure: 159/100 Temperature: 104 F Rapid heart beat. Completely dehydrated. Fever continued ... released same day and told to take Tylenol for fever. Stayed off sulfa/trimeth for two days. Got much better. Just took it tonight (foolishly) then found this page. Now realized that my body has been rejecting this drug. Currently itchy and cannot sleep. Took vicodin and ibuprofen - no effect to counter this drug. Must wait for it to leave the system. Will contact dermatologist in the morning about my allergic reaction to sulfa. Also experienced severe depression on this medication.