Been on Wellbutrin for almost 6 weeks now. Last week I started having a really itchy scalp, no flakes, just itchy and then bumps would appear where I had itched. My vaginal area was also itchy and I treated myself for a yeast infection unknowingly. This past weekend I broke out in what I now know was hives (urticaria angioedema). First my left ankle swelled (3 inches) and looked like it was sprained, but instead it was super itchy and then became achy and painful. Within 24 hours that ankle went down but the other side swelled up so badly that I had pitting edema in my ankle and could leave dents in it. The third day, still with constant scalp and ear itching, i developed hives and large welts on my inner thighs as well as a large welt on my shoulder. I have been taking benadryl, which seems to help the itching for a little, but not for long enough. Yesterday I was at work and my butt started to itch so badly I had to leave. I had developed huge welts in the creases between my leg and butt right were one sits on a chair! Huge 3-4 inches. I was so uncomfortable. My thumb also had swelled up and I could not move my left hand without burning itch and pain. I finally called the doctor and set up an appointment.
I was told to take benadryl 25-50mg, zantac 150mg twice a day, and Zyrtec once a day to control the hives. This has helped a bit.
When I saw the doctor today and we went over everything, the ONLY change in months has been the addition of the Wellbutrin. I am going to stop taking it today and since my story sounds much like the ones below hopefully this will improve before my eyes or throat swell! Thanks for all your posts.