I took Zoloft in varying strengths (50 - 150 mg) for four years and recently quit taking it cold-turkey. This is the second time I have tried this approach (not for any bad reason, just didn't feel like I needed the med anymore). Both times I have had symptoms return around the 3 month mark of not taking the medication. I never had any big side effects except sleepiness during the first few months of taking it. I've been fine since and think it was a very helpful medication but that it should be tapered off if at all possible.