Synthroid saved my mental well being and my life. When you first go on this medication, you can absolutely feel out of whack. First of all your body has to increase it's metabolism and is too tired to do it. It takes time for the hormone to be absorbed and then get the body back to functioning. Hair loss was not something that I had. But felt severely depressed after taking it. My doc told me that it was because my body was totally in a stress mode as it was trying to heal itself from being hypo. Went on paxil to ride out the storm, and have been totally find for over 6 years on both meds. My thyroid was so low it ran off the chart. A lot of women when discovering low thyroid are also simultaneously going through menopause or perimenopause. That is why the thyroid craps out. A lot of symptoms described in the other experiences here are menopause as well. Don't blame the synthroid. It will work and the hair loss is very temporary.