Same thing here. I have a sinus infection and pharyngitis that just wouldn't go away for 3 weeks. I was prescribed the generic version (Clarithromycin) 500Mg twice daily. The antibiotic does seem to work. I have had a bitter taste from it almost from the beginning. I took the fourth dose on an empty stomach in the morning with little fluid and 10 minutes later started to eat. 20 minutes after taking the antibiotic I had experienced an uncharacteristically severe panic attack. My heart just instantly started racing, confusion set in. The whole time while I am taking it I have difficulty breathing which eases off as dose wears out. Luckily for me I had some lorazepam laying around which I took to suppress this reaction. I skipped my 5th dose in the evening but my infection is still an issue. Now I am unsure whether to continue taking it or not. I am about to see my ENT today so I think I will not be taking it until I see him.