I was on Minocycline for about 6 consecutive months and found that it really helped my acne. I did not experience any bad side effects, except the first day where I had nausea. After 6 months I took it on and off for another 5-6 months, but found that it wasn't as effective anymore so I went back to my dermatologist. He said that for people who stop taking and start again it usually does not work as well anymore. I was on it for so long that the antibiotics started killing all my "good" bacteria and caused a urinary infection. My gyno suggested I talked to my dermatologist about taking me off the antibiotics. I went back and he put me on Loestrin24Fe ( a birth control pill). This was my last option, but we'll see how it goes.