I'm a 38 year old man and have been taking 300 mg of Wellbutrin for about 6 weeks now. The depression that I've been suffering with for years is gone! Which is a blessing. But, this week, I've been more irritable than ever. Not wanting to associate with anyone and verbally snapping at anyone who has crossed my path. Wasn't sure what was going on but I read irritability is a side-effect of Wellbutrin. I've also lost weight since being on Wellbutrin, thank goodness. I"m not constantly physically and mentally hungry like I used to be. My mouth is always dry, too. Other than the irritability I experienced this week, my side effect have not been bad and, overall, Wellbutrin has worked wonders for me.