These are not new side effects but a confirmation of some I've read. Two most disturbing are: the inability to cry which all my life has been a major way to release tension; weight gain and an inability to discipline myself to stop eating; addiction to sugar; lack of motivation; can't stick to anything. when I first started taking it my body "vibrated" but that stopped after a couple of months. However, my head sings all the time. It does cause heartburn so I have to take an antacid (but I also take other blood pressure meds which may add to this). I do generally feel better and now after nearly two years on Zoloft, my motivation to take on projects has increased. I exercise every day and it has helped with depression and anxiety but not with sleep. I'm afraid to go off it because of withdrawal symptoms I may have to suffer; so for now I'm going to continue taking it. It does cause weight gain and does lower motivation but since I'm 74 years old, I don't need to worry about sex drive. Hope this helps.