I was prescribed Simcor and had started taking it 4 days prior to an "attack". Out of the blue, the flushing, redness etc. No worries that is common I told myself. However, the severe burning and swelling set in. I had a splotchy rash that covered entire body and my face was the worst as it was swelling, effecting my neck, eyes etc. I did not wait to see what happens next. Straight to ER. Dr advised a good thing because it is potentially life threatening side effects for some. An IV with meds including steroids and 4 hours later the rash had subsided. Will not be taking this medicine again. Hope this helps.