I have been on Synthroid .2 for 31 years. Recently I had to add 3 half doses to what I already take. About 10 years ago I experienced rapid weight gain, 40 pounds, in two months. The doctor's reply, "I highly doubt that!" I literally got up one day and could not fit into my clothes. I don't know why doctors discount the drug for this symptom and for anxiety. It seems to me the adrenal gland would be affected by these hormones in some way which could cause stress symptoms. I called the manufacturer and they said they have no knowledge of Synthroid causing weight gain. Perhaps we should all contact the company and REPORT our side effects.