I was taking Nifediac CC 60mg for high blood pressure. I began having a bright red solid rash from my knees to my feet which itched, then the palms of my hands exhibited the same rash. Since we were on vacation, I went to an emergency room. The rash had faded, and the DR had no explanation for what I had. One week later, my arms and legs were swollen with huge hives. After hours, it meant another emergency room visit and this DR immediately took me off of Nifediac CC. The diagnosis was Hypersensitivity Vasculitis...an inflammation of the blood vessels. I've been off all medications with the exception of HCTZ. Interestingly enough...my blood pressure is within the normal range. Not sure what good Nifediac CC did for me except to make me sick.