I have been taking this medicine for three years. This morning I woke up and my right upper lip was completely swollen. While at the ER, the doctor said that it was a common side effect--even if the person had taken it for a prolonged period of time. I had to go back to the ER about 3 hours later because my mouth became even bigger! As I was checking in, a nurse looked at my mouth and said, "Oh, you take Lisinopril, right? I see that reaction all the time here, plus, I had it myself." The second Dr. came out and told me my airwaves and oxygen were okay and that I was just going to have to wait it out (they had earlier prescribed me Benadryl and a steroid). Then he explained he had to stop using the medicine himself because is tongue became swollen. This is a common occurrence. And if you are like me, you assume if you are going to have a reaction to a medicine, it's going to be rather early. This side effect can take time before it shows. Be careful, apparently it is a very common incident with this drug.