So glad I found this on the internet. I started taking Niaspan about 6 months ago..500mg at bedtime. I had some flushing, but nothing memorable. I have noticed that I will wake up with my heart beating fast, but I went right back to sleep each time. But, last night, I woke up at 1:30 am on fire..itchy, burning...and burning bad. It covered my face, upper chest, upper arms, buttocks, and the back of my thighs. Like many have said here, it felt like a very bad sunburn. My skin was hot to the touch, and red. I was so shocked and scared, that I almost went to the ER. It lasted for about 20 minutes, but then I got nauseated. I thought I was having a heart attack. I barely sleep all morning. I decided to search the internet, and found your posts. Thank you! I suspected it might be my niaspan, but then it could of been shingles or some heart problems. Know I have my answer. I'm calling my doctor first thing tomorrow. No more for me.