I had an asthma attack went to the er and got a breathing treatment and they gave me prednisone (not sure what dosage was) but they said it was a very high dose. After some other tests they sent me home. Got home at 830 that night and went to bed. Woke up around 1100 pm, with skin feeling like it was on fire and heart racing, chest heaviness. Couldn't sleep all night. Went to drs office next morning said I was having a reaction to prednisone. Oh by the way I was feeling very anxious as well all night pacing the floor. That was Friday night, it is Sunday night and still feeling a little anxious, heart racing, coughing, diarrhea, chest heaviness and can't sleep. All this from one dose of prednisone and a breathing treatment. I am sure that it is the prednisone because I did take it one other time about a year a go and had some of the same issues.