My 17 yr old son was prescribed Prednisone along with Accutane for Acne. His two older brothers had undergone accutane treatment when they were each 17 ish, with no major side effects - no mental disorders at all. They did not have Prednisone along with the accutane. I questioned why my youngest son should go on the prednisone but was assured by my trusted dr. of 35 years that his very low dose of 20mg a day would be no problem. We continued the dosage for 3 months and then tapered off for 3 weeks. That's when my son's trouble began. He felt a change immediately - things didn't seem 'real', he has a hard time describing the feelings. At two weeks after discontinuing the prednisone his symptoms really began to be very frightening. He is athletic and was vomiting for extended periods - probably due to the stress of what was going on in his head. We then saw 2 GPs, his Dermatologist and I contacted a Psychiatrist, His father and I didn't want him to progress to antidepressants and he does seem to be improving - nothing like some of the other stories contained here. I just wish we had NEVER gone on this - even at 20mg - for something like acne. NOT life threatening - I should have listened to my gut and just stuck with the Accutane.