In 2003 I started having panic attacks that lasted for 10-12 hours. My family doctor put me on Zoloft. I don't remember the dose, but think it may have been 10 mg. I became horribly depressed and had a severe aversion to eating. This is the exact opposite of my usual self. I fell into deep depression, to the point where I just laid on the couch. I lost 30 pounds in a month. My husband called my parents over, and they all said I had to go see a psychiatrist or they would put me in the hospital. I chose the first, and he put me on Xanax (alprazolam). Within 48 hours I was my old self. Unfortunately he prescribed the Xanax extended release ( just new on the market, so he got a kickback) and I suffered needlessly for months with delayed release of the medication and horrid expense. I finally asked my family doctor if there was a generic, and she said it had been around for years. For pennies a day, I have great relief. I have managed to wean myself down to 1 1/2 mg. a day, and can add more if going through a stressful time. We all have different reactions to meds. For me, Zoloft was a nightmare.