I have been taking Levoxyl for six months since a thyroidectomy in December 2008. Started on 137mcg, reduced to 125mcg, reduced to 100mcg, and now on 88mcg. I take it every morning on an empty stomach with plenty of water. I feel great and have not gained weight. I continue to eat healthy but probably don't exercise as much as I should. I consider myself a very lucky 54 year old woman.