OK ladies (and gentlemen too), I have just completed my second 6-month course of Lupron. The first time I had some side effects while on the medication (mood swings, hot flashes, massive - 40 lbs! - weight gain, memory and concentration problems, aches and pains, etc) - but the withdrawal was worse. I was trying to plan my best friend's bridal shower and couldn't do it because I was mentally non-functional, and I had diarrhea and other unpleasant effects. Within six months, however, I was able to hold a full time job, take graduate level classes, and do all my other activities. And Lupron gave me 12 symptom-free years - I was sure my endo was cured.
After I found out otherwise last fall, that I had huge endometrial cysts again PLUS some small fibroids (the result of all the pills and progestins I'd taken trying to help the endo), I faced surgery and Lupron again. My doctor was extremely conservative and JUST took out the large cyst on one side - leaving several smaller ones on the other side as well as ALL the adhesions. He recommended Lupron again, and I decided to take the bull by the horns and to do what I could to help myself.
During the course of Lupron treatment, I tried to consume at least 40 mg of soy (soy only!) isoflavones per day. I avoided beer, yams and other phyto-progestins. I upped my consumption of milk and other calcium-rich foods; if I craved sweets, I binged on them. In other words, I listened to my body.
Recent research has shown that the hot flashes and memory problems associated with menopause are the result of changes in the processing of carbohydrates that causes too little glucose to reach the brain. Likewise, I have read that the joint pains associated with Lupron are caused by the drug's undermining the liver's ability to produce glucosamine, another glucose-derivative. I noticed that when I would have symptoms and would, for example, eat sweets (no, fruit won't do), my mental symptoms would subside and my joints would almost immediately feel better. I realize most doctors would stone me for this advice, and I have gained 15 lbs - but I have /only/ gained 15, whereas I gained 40 before while attempting to eat right and exercise.
I have also found that MSM, especially when combined with chicken collagen, almost instantly helps my joints. The glucosamine/chondroitin formulations I tried tended to make me dizzy - again, probably something to do with the Lupron's effects on the liver.
For my immune system I have been taking Coenzyme Q10 and Juice Plus, a fruit and vegetable blend available online (www.juiceplus.com).
I won't say I haven't had side effects either while on the Lupron or since going off, but I have been functioning much better thus far than I did while on or immediately after going off the Lupron before. Can't hurt to try it. Good luck!