Well, I have been on Effexor 75mg for about six months. I certainly haven't lost my sense of humor, but the weight gain I have experienced is no laughing matter (25 lbs). I do know that my appetite has strongly increased -- eating all the time, and I started smoking cigarettes again; I think this drug makes me too relaxed and I feel indifferent to many things... Maybe wanting to eat & smoke is a desire to get "highs", as this drug makes me feel too lifeless. I have decided to wean myself from this drug on my own (starting tomorrow), because I want my appetite to go away, and I miss the higher sex drive I once had. Also this drug has given me a feeling that I am "not myself"... like "personality disintegration"... Who am I?
Anyway, I shall let you know how I make out during my withdrawls... Oh, incidentally, I also have experienced "shock-like" twitches in my head (times when I miss just one dose)... Wish me luck!!