I've been on it for just over one year and I have had great success with Topamax for my chronic migraines! I am at 200mg a day. I use to wake up with migraines in the morning and that has been greatly reduced. I use to never know when they would hit me and now I can figure out when which is usually hormonal - during my period. Before we (my neurologist and I) settled on the right dosage, we kept bumping up in 25 mg at a time and i would have side effects ... unpleasant (smelly gas, tingling fingers, other stuff i don't remember anymore), but after a few weeks, the side effects would go away. Now I don't have any side effects. I did loose weight, but only 5 lbs. I made a conscience effort to eat right and drink plenty of water because I read the forums about the bad health effects of the drug. I do loose words sometimes, but its a small trade-off for the migraines. Now, if I could just find something that would tame the hormones... Cheers!