I just learned that you can develop Cushing's Syndrome from taking prednisone, and that the doctor that has you on this should warn you that you could develop this. 10 mg a day usually worked for my pain, but I eventually got up to 20 mg a day, and that's when my problems really started. Of course I had already gained enough weight, which caused severe depression, but then I started gaining like crazy, and this is really weird, I was eating less, and had no appetite, but still gaining weight. I started feeling too tired to do anything, I have severe lower back pain, and get short of breath from any little bit of activity I do. I can't even take a shower without sitting on the side of the tub to rest. I also started having restless leg syndrome at night and would wake up several times. I sweat profusely without doing anything. I can just be sitting on the couch watching tv and sweat will start pouring down my face. I keep a towel with me at all times to wipe the sweat off. I definitely have moon face, and I also have sores all over my legs and face. I wish I would wake up and it was all a bad dream, but not so. I feel for everyone that has had these experiences. I am seeing an endocrinologist next week to see if I have Cushing's Syndrome. I don't even know if there is anything to do for it? Has anyone else who has used prednisone been diagnosed with Cushing's Sydrome?