I started on the Wellbutrin almost 3 weeks ago. Other than a little problem with insomnia, I really liked the medication. It seemed to be helping me control my binge eating which definitely a plus and also the depression. One morning, I woke up with hives all over my body. A few hours later, they had become very severe. I had hives there were 8 inches long and hive patches about 8X12. They were in my scalp, neck, arms, upper legs, back, stomach. Went to family doctor who gave me shot and started on prednisone and was also taking benadryl. That night the itching was so severe, had to go to ER for IV steroids. This calmed things down tremendously. Haven't gone totally away yet, but much better and more bearable. It's a shame because I was feeling very hopeful on the medication. I was taking the generic form at 150 mg 2x day.