Foot pain, to the extent that I cannot touch the bones in my feet. I had moderate heel spur pain which became extreme when I tried to resume the synthroid, even a minor 25mcg dose of synthroid. Bone and joint pain in the past made me stop taking the synthroid, especially shoulder and upper arm weakness on one occasion, and leg weakness and foot pain on the second occasion. This third time was related to heel, ankle and the bones in my feet. These problems went away within 5 days of not taking this medication.