I have been taking lotrel 10-20 for several years with only swelling of the feet and ankles. I have gained over 20 pounds with no change in diet. Dr. bumped up the dose to 10-40 for the past week and I have severe headaches and severe flushing. I am going to go back to the 10-20 to see if this helps. If it does not help, I will request a different med.