I was given a 30 day supply of minocycline from my doc to treat my eczema. At first, no side effects and eczema did clear up. About 1 week in, I started to feel physically run down. Second week I began to feel not just physically, but also mentally down. By week 3 I was in the throws of full on horrible depression. With one week left to go I stopped taking anymore of my 100 mg pills. After 2 days of going off minocycline, I feel so much better. Really, it's like the difference between day and night. No doubts what soever that this stuff causes depression.