I am a 62 year old male who works out and is in good shape. I developed a case of diverticulitis and was prescribed a 10 day course of Avelox, 400 mg. per day. I began taking the pills and they worked on the diverticulitis. However, after 7 pills, I developed pain above and below the knees and down at the ankle. This pain is in the tendons. It feels like a permanent Charlie Horse. I went to the doctor today and his belief is that I do indeed have a side effect, since I am in otherwise good health, the pain is in both legs, and the onset coincides with taking Avelox. Unfortunately, he said they do not really know the mechanism of this reaction; they don't know how long it lasts; don't know if it goes away, etc. Now I must really watch myself for who knows how long because of the danger of popping a tendon. This is incredible to me. Seven pills and perhaps permanent damage? I am wondering if any of the people who have posted tendon issues have improved or gotten worse after time.