My 8 year old daughter started Lupron about six months ago due to precocious puberty. She started her period about eight months ago so we saw an Endocrinologist who told me there were NO SIDE EFFECTS. With the second shot, I noticed mood swings and tearfulness that I had never seen before. With the third shot, she had a rash for one day that was relieved by Benadryl. She no longer has mood swings and has not had a rash again but she has gained 8 pounds and I have noticed hair loss. The front of her hair is twice as long as the back. Her doctor has recommended that she stay on the shots until she is 11. Now that she is 9, I have decided to stop the shots and we will just have to deal with her having a cycle so young. It was a difficult decision for me to start her on the injections, but I made the decision believing that there were no side effects. This may be true in some patients, but it was not true for us. I just hope she can lose the weight and that the hair loss is not permanent.